A case of valproate induced non-hepatic hyperammonemic encephalopathy

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A Case of Valproate Induced Hyperammonemic Encephalopathy

A 36-years-old man on phenytoin, levetiracetam, and sodium valproate presented with acute confusion. Routine investigations including serum valproate and phenytoin concentration were normal. His serum ammonia concentration was raised. His valproate was held and 2 days later he recovered with concordant normalisation of serum ammonia concentration. Urea acid cycle disorder was ruled out, and a d...

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Valproate-Induced Hyperammonemic Encephalopathy

Valproate is the best choice drug for a variety of medical conditions. As with any other drug, it has adverse effects, and it is important to emphasize the possibility of those adverse effects to prevent complications. We present the case history of a 44-year-old male with valproate-induced hyperammonemic encephalopathy, despite having normal liver function tests. This case includes a detailed ...

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Non-Hyperammonemic valproate encephalopathy

A 21-year-old male known case of primary hypothyroidism, Seizure disorder sequelae of an old trauma receiving sodium valproate, clobazam and phenobarbitone for control of Generalized tonic clonic seizures reported to neurology OPD with history of altered sensorium and gait unsteadiness for 1 week with history of hike in valproate dose 2 weeks before. On examination he was drowsy. Neurological e...

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[Valproate-induced hyperammonemic encephalopathy].

Encefalopatia hiperamonemica inducida por acido valproico.

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Valproate-associated hyperammonemic encephalopathy.

The use of valproic acid (VPA) (also known as Depakote, Depakene, and others) frequently results in elevated plasma ammonia. In some people, hyperammonemia may be clinically significant, resulting in hyperammonemic encephalopathy, which may be severe. Valproic acid-induced hyperammonemic encephalopathy may occur in people with normal liver function, despite normal doses and serum levels of VPA....

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ژورنال

عنوان ژورنال: International Journal of Basic and Clinical Pharmacology

سال: 2016

ISSN: 2319-2003

DOI: 10.18203/2319-2003.ijbcp20163278